Acute kidney injury

Oxidative stress – when oxygene becomes a threat

Oxygen is a prerequisite for life. But there are times when the body begins to transform oxygen into substances that cause oxidative stress. This can lead to very serious damage on organs and tissue, such as acute kidney injuries.

Acute kidney damage and oxidative stress – a global challenge
Abundant oxidative stress in the kidney can for example appear due to invasive surgical interventions, chemotherapy, kidney transplantation and sepsis. Acute kidney injury (AKI) is a dreaded consequence; a condition that quickly leads to impaired kidney function, with negative effects on essentially all bodily functions. Without functioning kidneys, life-supporting dialysis is a necessity.

More than 13 million people are affected by AKI every year. The mortality is high, and survivors are at risk of developing a chronically reduced kidney function, with all the implications of that in terms of increased morbidity and reduced quality of life. There are no effective therapies available today to prevent or treat AKI.

AKI in cardiac surgery – our focus
We have chosen to initially focus the clinical development of ROSgard for the prevention and treatment of AKI in patients undergoing cardiac surgery. Considering ROSgard's mode of action and convincing preclinical results, this is an attractive indication with high potential to demonstrate clinical proof-of-concept. Moreover, this indication offers a number of developmental advantages, for example a large patient base, short duration of treatment, and well-defined clinical endpoints that are accepted by the regulatory authorities.

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